生物医疗学系

최수영
  • Field

    生化学

  • Name

    Korean 崔水荣

  • Title

    教授

  • Office

    自然科学大学生物医疗学系 8409

  • Tel

    033-248-2112

  • email

Educational background

• University of Tennessee, Knoxville, 美国 (生化学)

• 延世大学(理学硕士-生化学)

• 延世大学(理学士-生化学) 

 

■ Homepage : http://web.hallym.ac.kr/~sychoi/

Major careers

• 韩国生化学分子生物学会 会长

• 江原道国际会议产业支援中心 理事长

• 翰林大学 副校长

• 韩国生化学分子生物学会 副会长

• 韩国脑神经科学会 会长

• 翰林大学 副校长

• 韩国科学技术翰林院 正式会员

• 生化学分子生物学会学术杂志(BMB Reports) 编辑委员长

• 翰林大学教务研究处长

• 春川生物产业振兴院 理事

• 翰林大学产学协力团长

• 翰林大学策划处长

• 翰林大学教务副处长

• 研究员

Studies & Books

• 生化学(蛋白质生化学, 神经生化学)

• 蛋白质渗透技术(Protein Transduction Technology)

• 蛋白质治疗(Protein Therapy) 

Others

• 韩国生化学分子生物学会

• 韩国分子细胞生物学会

• 韩国脑神经科学会

• 国际神经化学会

• 韩国遗传学会

• 科学技术优秀论文奖 (1996, 2004)

• 总统表彰 (2001)

• 江原人大奖 (2005)

• 江原道文化奖 (2011)

• 第6届东谷奖 (2011) 

박진서
  • Field

    면역학, 바이러스학

  • Name

    Korean 朴振绪

  • Title

    教授

  • Office

    生物医疗学系 8411

  • Tel

    033-248-2116

  • email

Educational background

• 阿拉巴马大学, 美国 伯明翰 (博士-微生物学)

• 韩国科学技术院(理学硕士-生物工学系)

• 延世大学(理学士-食品工学系) 

Major careers

• 自然科学大学校长 

• 生物医疗学系BK团长

• 生物医疗学系长

• 研究处长

• 产学协力团长, 

Studies & Books

■ Representative Publications (2011 ~ present)

1) Jo H, Jang HY, Youn GS, Kim D, Lee CY, Jang JH, Choi SY, Jun JG, Park J. 2018. Hindsiipropane B alleviates HIV-1 Tat-induced inflammatory responses by suppressing HDAC6-NADPH oxidase-ROS axis in astrocytes. BMB Rep. 51:394-399.

 

2) Youn GS, Cho H, Kim D, Choi SY, Park J. 2017. Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes. Redox Biol. 12:978-986.

 

3) An SY, Youn GS, Kim H, Choi SY, Park J. 2017. Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes. BMB Rep. :25-30

 

4) Youn GS, Lee KW, Choi SY, Park J. 2016. Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages. Free Radic Biol Med. 97:14-23.

 

5) Kim H, Youn GS, An SY, Kwon HY, Choi SY, Park J. 2016. 2,3-Dimethoxy-2'-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells. BMB Rep. 49(1):57-62.

 

6) Park SH, Shin MJ, Kim DW, Park J, Choi SY, Kang YH. 2016. Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein. Int J Mol Med. 37(2):387-397.

 

7) Youn GS, Ju SM, Choi SY, Park J. 2015. HDAC6 mediates HIV-1 Tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes. Glia. 63(11):1953-1965.

 

8) Kim YN, Kim DW, Jo HS, Shin MJ, Ahn EH, Ryu EJ, Yong JI, Cha HJ, Kim SJ, Yeo HJ, Youn JK, Hwang JH, Jeong JH, Kim DS, Cho SW, Park J, Eum WS, Choi SY. 2015. Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice. Toxicol Appl Pharmacol. 286(2):124-134.

 

9) Seo WY, Youn GS, Choi SY, Park J. 2015. Butein, a Tetrahydroxychalcone, Suppresses Pro-inflammatory Responses in HaCaT Keratinocytes. BMB Rep. 48(9):495-500.

 

10) Kim MJ, Park M, Kim DW, Shin MJ, Son O, Jo HS, Yeo HJ, Cho SB, Park JH, Lee CH, Kim DS, Kwon OS, Kim J, Han KH, Park J, Eum WS, Choi SY. 2015. Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model. Biomaterials. 64:45-56.

 

11) Yoon CH, Kim SY, Byeon SE, Jeong Y, Lee J, Kim KP, Park J, Bae YS. 2015. p53-Derived Host Restriction of HIV-1 Replication by Protein Kinase R-Mediated Tat Phosphorylation and Inactivation. J Virol. 89(8):4262-4280.

 

12) Ju SM, Youn GS, Cho YS, Choi SY, Park J. 2015. Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses via suppression of NF-κB activation in the RINm5F beta cells. BMB Rep. 48(3):172-177.

 

13) Youn GS, Kwon DJ, Ju SM, Rhim H, Bae YS, Choi SY, Park J. 2014. Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes. Toxicol Appl Pharmacol. 280:42-52.

 

14) Kwon DJ, Bae YS, Ju SM, Youn GS, Choi SY, Park J. 2014. Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages. BMB Rep. 47(6):318-323.

 

15) Kwon DJ, Bae YS, Ju SM, Youn GS, Choi SY, Park J. 2014. Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages. BMB Reports. 47(6):318-323.

 

16) Shin MJ, Kim DW, Lee YP, Ahn EH, Jo HS, Kim DS, Kwon OS, Kang TC, Cho YJ, Park J, Eum WS, Choi SY. 2014. Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury. Free Radic Biol Med. 67:195-210.

 

17) Youn GS, Kwon DJ, Ju SM, Choi SY, Park J. 2013. Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. BMB Reports 46(8):410-415.

 

18) Kwon DJ, Ju SM, Youn GS, Choi SY, Park J. 2013. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages. Food Chem Toxicol. 58:479-486.

 

19) Kim MJ, Kim DW, Park JH, Kim SJ, Lee CH, Yong JI, Ryu EJ, Cho SB, Yeo HJ, Hyeon J, Cho SW, Kim DS, Son O, Park J, Han KH, Cho YS, Eum WS, Choi SY. 2013. PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radic Biol Med. 63:432-445.

 

20) Ju SM, Goh AR, Kwon DJ, Youn GS, Kwon HJ, Bae YS, Choi SY, Park J. 2012. Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells. Mol Cells. 33(4):335-341.

 

21) Kwon DJ, Bae YS, Ju SM, Goh AR, Youn GS, Choi SY, Park J. 2012. Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-κB and STAT1 activation in HaCaT cells. Biochem Biophys Res Commun. 2012 417(4):1254-1259.

 

22) Lee SH, Kim DW, Kim HR, Woo SJ, Kim SM, Jo HS, Jeon SG, Cho SW, Park JH, Won MH, Park J, Eum WS, Choi SY. 2012. Anti-inflammatory effects of Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma. Biochem Biophys Res Commun. 417(3):1024-1029

 

23) Song HY, Ju SM, Seo WY, Goh AR, Lee JK, Bae YS, Choi SY, Park J. 2011. Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes. Free Radic Biol Med. 50(5):576-584.

 

24) Seo WY, Goh AR, Ju SM, Song HY, Kwon DJ, Jun JG, Kim BC, Choi SY, Park J. 2011. Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells. Biochem Biophys Res Commun. 407:535-540.

 

25) Kwon DJ, Bae YS, Ju SM, Goh AR, Choi SY, Park J. 2011. Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells. Biochem Biophys Res Commun. 409:780-785.

 

26) Kim SY, Sohn EJ, Kim DW, Jeong HJ, Kim MJ, Kang HW, Shin MJ, Ahn EH, Kwon SW, Kim YN, Kwon HJ, Kim TY, Lee KS, Park J, Eum WS, Choi SY. 2011. Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice. J Invest Dermatol. 131:1477-1485.

 

27) Kwon SW, Sohn EJ, Kim DW, Jeong HJ, Kim MJ, Ahn EH, Kim YN, Dutta S, Kim DS, Park J, Eum WS, Hwang HS, Choi SY. 2011. Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model. Biochem Biophys Res Commun. 411::354-359.

Others

■ Awards

1) Fellowship, 1987-1991, Department of Microbiology
University of Alabama at Birmingham

 

2) Korean National Fellowship, 1981-1983, Department of Biological Sciences
Korea Advanced Institute of Science and Technology

 

3) Academic Award, 2015. 11. 13, 2015 Annual Meeting of The Korean Society for AIDS
The Korean Society for AIDS

 

 

주요연구주제
• Pathogenesis of AIDS by HIV, Development of therapeutic tools using protein transduction technology, Development of therapeutic materials against inflammatory diseases 


■ Societies
• The Korean Society of Virology 
• The Korean Society for Biochemistry and Molecular Biology 
• The Korean Society for Molecular Biology and Cell Biology 
• The Korean Society for AIDS

 

■ Research interests and current research (Laboratory of Virology and Immunology)

 

1) Background

The global spread of HIV infection and AIDS continues while current therapies are very limited and effective vaccines are nonexistent. Accordingly, novel therapeutic approaches must be devised to target viral gene functions that regulate virus replication and produce disease. Thus, understanding of viral gene function may not only lead to the elucidating the viral pathogenesis, but also may provide new approaches to inhibit HIV replication and/or preventing disease progression.

 

2) Elucidation of the role of Tat in the pathogenesis of HIV

Tat is a transcription transactivator produced by the human immunodeficiency virus type 1 (HIV-1) at the early phase of infection and plays an essential role in the expression and replication of the viral genome. Tat protein, which can be secreted from the infected cells, has the ability to enter uninfected cells and exert its activity upon the variety of cellular genes, suggesting Tat may affect various cell types in the central nervous system, potentially contributing to the development of AIDS-associated neurological disease. We are currently studying the biological effects of exogenous Tat on cells from the central nervous system (astrocyte and neuronal cell) and the lymphoid T cells (Jurkat). This study will elucidate the critical role of Tat in molecular pathogenesis of AIDS dementia leading to development of therapeutic tools for this disease.

 

3) Development of protein transduction technology

Protein therapy is based on the delivery of target proteins into cells instead of traditional chemotherapy to treat human diseases. Based on the recent findings that abnormal activity of cellular proteins is responsible for the generation of a variety of human diseases, development of therapeutic agents could be achieved by regulating the biological activity of these proteins. Nevertheless proteins are superior to other chemicals in the selectivity and efficacy of their action mode, utilization of these proteins as the therapeutic drugs is severely limited due to the difficulty of delivery of therapeutic proteins into cells. To overcome this problem, it is necessary to develop a novel technology by which a variety of biologically active proteins could be delivered into cells. This protein transduction technology is based on the previous findings that exogenous HIV-1 Tat protein was able to translocate through the plasma membrane and to reach both the cytosol and nucleus in the cell. By exploiting this property of Tat, we are currently developing a system for the delivery of biologically functional peptide/protein into target cells or tissues.

 

4) Directions for the anti-inflammatory drug discovery

- Utilize cell-based assays and in vivo testing strategies for the development of anti-inflammatory drugs.

- is initially directed towards discovering inhibitors from natural products and recombinant proteins.

 

 

■ Patents (2015~ 현재)

1) 미국특허등록

(1) Eye drop composition for prevention and treatment of ophthalmic diseases containig fusion protein of FK506 Binding Protein

등록일 2015.2.24 등록번호 8,962,567

 

2) 국내특허등록

(1) 세포투과성 NQO-1 융합단백질을 포함하는 뇌허혈 치료용 약학조성물

등록일: 2015.11.14 등록번호: 10-1677449

(2) 글루타레독신 1 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물

등록일: 2016. 10. 26 등록번호: 10-1671197

(3) 세포투과성 NQO1 융합단백질을 함유하는 뇌허혈 치료용 약학 조성물

등록일: 2016. 11. 14 등록번호: 10-1677449

(4) 세포투과성 PIM2 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물

등록일: 2017. 04. 26 등록번호: 10-1732349

(5) PEA15 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물

등록일: 2017. 07. 20 등록번호: 10-1761550

(6) 사이토카인 유도 세포자기사멸 저해제 1 융합단백질을 포함하는 항염증 약학 조성물

등록일: 2018. 06. 15 등록번호: 10-1869686

한규형
  • Field

    分子遗传学

  • Name

    Korean 韩奎炯

  • Title

    教授

  • Office

    自然科学大学生物医疗学系 8401

  • Tel

    033-248-2115

  • email

Educational background

• 哥倫比亞大学, 美国(博士-生物学系)

• 首尔大学(理学硕士-微生物学系)

• 首尔大学(理学士-微生物学系) 

Major careers

• Pre-Med 协同专业过程主任教授

• 生物医疗学系长

• 生命工学研究所所长

Studies & Books

■ 논문

 

주저자 : 제1저자, 공동저자(교신), 단독


• Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1 [BMB Reports, SCI급, 공동(교신), 2015] 

 

• Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor [BMB Reports, SCI급, 공동(교신), 2013] 

 

 

공동저자 : 공동저자(참여)


•  PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models [Immunobiology, SCI급, 공동(참여), 2018] 


•  Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults [Free Radical Biology and Medicine, SCI급, 공동(참여), 2016] 

Others

• 中小企业厅奖状 (2011)

• 校外研究费受益现况(以研究负责人为准)

조윤신
  • Field

    微生物学

  • Name

    Korean 赵胤新

  • Title

    教授

  • Office

    自然科学学院生物医疗学科 8407

  • Tel

    033-248-2111

  • email

Educational background

• 美国伊利诺伊大学分子生物学专业(博士)

• 美国威斯康星大学微生物学专业(硕士)

• 西江大学生物学专业(硕士)

• 西江大学生物学专业(学士) 

Major careers

• 翰林大学BK21 PLUS事业部长

• 翰林大学生物医疗学系长

• 疾病管理总部保健医疗技术评估管理专业委员会 委员

• 疾病管理总部资料·资源利用审议委员会 委员

• 韩国研究财团生命科学团 专业委员

• 韩国科学技术翰林院先驱科学者                                                                                                                                                                                           

• Pre-Med协同过程主任教授

• 翰林大学自然科学大学生物医疗学系 教授

• 疾病管理总部国立保健研究员基因组中心 保健研究员

• 疾病管理总部国立保健研究员基因组中心 责任研究员

• 汉阳大学生命科学系 研究教授

• 美国宾夕法尼亚大学医科大学, 博士后过程研究员

• 翰林大学遗传工学系 专任助教

Studies & Books

• 基因组研究

Others

• 韩国基因组学会

• 生化学分子生物学会

이근욱
  • Field

    癌生物学

  • Name

    Korean 李根旭

  • Title

    教授

  • Office

    自然科学馆 8411

  • Tel

    033-248-2113

  • email

Educational background

• 延世大学生化学系(理学博士)

• 延世大学生化学系(理学硕士)

• 延世大学生化学系(理学士)

Major careers

• 翰林大学生物医疗学系(助教)

• 延世大学医科大学医学生命科学部(研究教授)

• 翰林大学医科学研究所(研究讲师)

Studies & Books

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53 (2018) Oncogene. Epub ahead of print

 

Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis (2018) Am J Pathol. Epub ahead of print

 

Gomisin G suppresses the growth of colon cancer cells by attenuation of Akt phosphorylation and arrest of cell cycle progression (2018) Biomol Ther. Epub ahead of print

 

PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models (2018) Immunobiology. Epub ahead of print.

 

PEP-1-glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptosis signaling pathway (2018) Mol Med Rep. 18:2216-2228

 

Gomisin G inhibits the growth of triple-negative breast cancer cells by suppressing AKT phosphorylation and decreasing cyclin D1 (2018) Biomol Ther. 36:322-327

 

B cell-intrinsic mTORC1 promotes germinal center-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity. (2018) J Immunol. 200:2627-2639.

 

CD11b regulates antibody class switching via inducing AID (2017) Mol Immunol. 87:47-59

 

Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway (2017) Mol Brain. 10:1

 

 

Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults (2016) Free Radic Biol Med. 97:2501262

 

Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kB/AP-1 signaling pathways in macrophages (2016) Free Radic Biol Med. 97:14-23

 

Aronia melanocarpa Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice (2016) J Med Food. 19:654-662

 

Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model (2016) Int J Mol Med. 38:217-224

 

Extracellular release of CD11b by TLR9 stimulation in macrophages (2016) PLoS One. 11:e0150677

 

Rapamycin-resistant and torin-sensitive mTOR signaling promotes survival and proliferation of leukemic cells (2016) BMB Rep. 49:63-68

 

Monoclonal antibodies against the human respiratory syncytial virus obtained by immunization with epitope peptieds and CpG-DNA-liposome complex (2015) Monoclon Antib Immunodiagn Immunother. 34:101-109

 

Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischaemic insult in animal model (2015) J. Cell. Mol. Med. 19:1333-1345

 

Effect of respiratory syncytial virus on hepatocellular carcinoma cell lines (2015) BMB Rep. 48:565-570

 

Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways (2015) Mol. Cell. Biol. 35:1299-1313

 

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells (2014) J. Exp. Med. 211:2281-2295.

 

Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer (2014) Gut Liver. 8: 1-9

 

Crosstalk between Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling (2013) Mol. Cell. Biol. 33: 4152-4156

 

Requirement for Rictor in homeostasis and function of mature B lymphoid cells (2013) Blood. 122: 2369-2379

 

Cdc42 promotes host defenses against fatal infection (2013) Infect. Immun. 81:2714-2723

 

STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation (2013) J. Immunol. 191:678-687

 

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction (2013) Blood. 121:3619-3630

 

Effects of cancer-associated Epha3 mutations on lung cancer (2012) J. Natl. Caner Inst. 104:1083-1098

 

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia (2012) J. Exp. Med. 209:713-728

 

A “Tsc, Tsc” keeps the kids quie(scen)t and holds off ROS (2011) Nat. Immunol. 12:811-812

 

Control of macrophage responses on hydrophobic and hydrophilic carbon nanostructures (2011) Carbon. 49:2092-2103

 

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways (2010) Immunity. 32: 743-753

Others

■ 주요연구주제
• PI3K/mTOR signaling networks and immunity

• Immunoediting factors and tumor microenvironment

• Immunophenotyping and pathogen infection service of genetically engineered mice


■ 학회활동
• 생화학분자생물학회 운영위원회

• 한국실험동물학회 학술위원회

• American Association of Immunology 회원

박종국
  • Field

    RNA 생물학

  • Name

    Korean 박종국

  • Title

    조교수

  • Office

    生物医疗学系 8404

  • Tel

    033-248-2114

  • email

Educational background

2006 – 2012 Ohio State University, USA (Ph.D-약제학과)

2001 – 2003 가톨릭대학교 성의교정 (의학석사-약리학)

1998 – 2001 건국대학교 수의과대학 (수의학석사-수의내과학)

1994 – 1998 건국대학교 수의과대학 (수의학사-수의학)

Major careers

2017 – 현재
한림대학교 자연과학대학 바이오메디컬학과 (조교수)

 

2012 – 2017
Department of Dermatology at Northwestern University Feinberg School of Medicine (Postdoctoral Fellow)

 

2012 – 2012
Division of Pharmaceutics, College of Pharmacy, The Ohio State University (Postdoctoral Fellow)

 

1998 – 2000 건국대학교 수의과대학 전임조교

Studies & Books

microRNA와 autophagy

- 윤부줄기세포(limbal stem cells)에서 microRNA에 의한 줄기세포 특성 및 autophagy 조절기전 연구

- 각막상피세포(corneal epithelial cells)에서 microRNA에 의한 각막세포재생, 신생혈관형성, autophagy 조절기전 연구

- MicroRNA에 의한 암세포의 성장, 전이, 세포사멸 기전연구

 

 

■ 논문 : 주저자 : 제1저자, 공동저자(교신), 단독

 Moeng S, Seo HA, Hwang CY, Cipolla GA, Lee DJ, Kuh HJ, Park JK. MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide. Anticancer Res. 2018 Nov. In production.

 

Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ. Combinatorial Antitumor Activity of Oxaliplatin with Epigenetic Modifying Agents, 5-Aza-CdR and FK228, in Human Gastric Cancer Cells. Biomol Ther (Seoul). 2018 Sep 3. In production.

 

Park JK, Doseff A, Schmittgen TD. MicroRNAs targeting caspase-3 and -7 in panc-1 cells. Int J Mol Sci. 2018 Apr 16;19(4). pii: E1206 (corresponding author).

 

 Peng H, Park JK, Lavker RM. Eyeing Autophagy and Macropinocytosis in the Corneal/Limbal Epithelia. Autophagy. 2017 May 4;13(5):975-977 (co 1st author).

 

 Peng H, Park JK, Lavker RM. Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/limbal Epithelia. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):416-423 (co 1st author).

 

Park JK, Peng H, Yang W, Katsnelson J, Volpert O, Lavker RM. microRNA-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J. 2017 Jan 1; 31(1):256-265.

 

Park JK, Peng H, Katsnelson J, Yang W, Kaplan N, Dong Y, Rappoport JZ, He C, Lavker RM. microRNAs-103/107 coordinately regulate macropinocytosis and autophagy. J Cell Biol. 2016 Dec 5;215(5):667-685.

 

Park JK, Yang W, Katsnelson J, Lavker RM, Peng H. microRNAs enhance keratinocyte proliferative capacity in a stem cell-enriched epithelium. PLoS One. 2015; 10(8): e0134853.

 

 Peng H, Park JK, Katsnelson J, Kaplan N, Yang W, Getsios S, Lavker RM. microRNA-103/107 family regulates multiple epithelial stem cell characteristics. Stem Cells. 2015; 33(5):1642-56 (co 1st author).

 

 Elgamal OA, Park JK, Gusev Y, Azevedo-Pouly AC, Jiang J, Roopra A, Schmittgen TD. Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation. PLoS One. 2013; 2;8(10):e76402 (co 1st author).

 

Park JK, Kogure T, Nuovo GJ, Jiang J, He L, Kim JH, Phelps MA, Papenfuss TL, Croce CM, Patel T, Schmittgen TD. miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res. 2011; 71(24): 7608-16.

 

Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD. miR-132 and miR-212 are increased in pancreatic adenocarcinoma and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011; 406(4): 518-23.

 

 Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S, Schmittgen TD. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2010; 403(1): 120-5 (co 1st author).

 

 

■ 논문 : 공동저자 : 공동저자(참여)

 Khawar IA, Park JK, Jung ES, Lee MA, Chang S, Kuh HJ, Three dimensional mixed-cell spheroids mimic stroma-mediated chemoresistance and invasive migration in hepatocellular carcinoma, Neoplasia 2018 2018 Jul 4;20(8):800-812.

 

 Cipolla GA, Park JK, Lavker RM, Petzl-Erler ML. Crosstalk between Signaling Pathways in Pemphigus: A Role for Endoplasmic Reticulum Stress in p38 Mitogen-Activated Protein Kinase Activation? Front Immunol. 2017 Sep 5; 8: 1022.

 

 Kim JH, Badawi M, Park JK, Jiang J, Mo X, Roberts LR, Schmittgen TD. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016 Nov;49(5):2037-2045.

 

 Cipolla GA, Park JK, de Oliveira LA, Lobo-Alves SC, de Almeida RC, Farias TD, de S Lemos D, Malheiros D, Lavker RM, Petzl-Erler ML. A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. Biochim Biophys Acta. 2016 Oct;1859(10):1306-13.

 

 Lee SH, Nam JK, Park JK, Lee JH, Min DS, Kuh HJ. Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model. Oncol Rep. 2014; 32(4):1427-34.

 

 Kim TW, Cui R, Jeon YJ, Lee JH, Lee JH, Sim HS, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM. Long-range interaction and correlation between MYC enhancer and oncogenic lncRNA CARLo-5. Proc Natl Acad Sci U S A. 2014; 18;111(11):4173-8.

 

Others

학회활동

2018 ~ 현재, Oncology Letters, Editorial Board Member  

2006 – 현재, 미국 암학회 (AACR)

2012 – 현재, 미국 안과 및 시과학회 (ARVO)

미국 고든 리서치 세미나 의장 (Cornea, Biology & Pathobiology of the Gordon Research Seminar, 2016년)