生命科学系

한상진
  • 领域

    동물생리학, 생체주기학, 생태학

  • 姓名

    Korean 韓相辰

  • 职位

    生命科学部(生物学专业) / 教授

  • 研究室

  • 联系方式

    (033) 248-2094

  • 电子邮件

学历

梨花女子大学生物学系(学士)

德国蒂宾根大学生物学系(Diplom)

德国蒂宾根大学生物学系(Ph. D.)

主要经历

德国蒂宾根大学研究员

翰林大学生物学系 助教

翰林大学自然科学大学生物学系 副教授

翰林大学自然科学大学生命科学部 教授

研究及著作

动物生理学, 生体周期学, 生态学

其它

■ 연구분야

- 동물생리학, 생체주기학, 생태학 

김영동
  • 领域

    植物多样性

  • 姓名

    Korean 金荣东

  • 职位

    教授

  • 研究室

    生命科学馆8310

  • 联系方式

    033-248-2095

  • 电子邮件

学历

首尔大学, 植物学系学士(植物学专业)

首尔大学, 研究生院植物学系硕士(植物分类学专业)

德克萨斯大学, 研究生院植物学系博士(植物分子系统学专业) 

主要经历

韩国植物分类学会杂志 编辑委员长

研究及著作

 

 

其它

通过植物的遗传信息分析发掘系统分类和新种
利用分子标记的韩国主要植物的出现
韩国和东南亚(柬埔寨, 缅甸)植物奖
为保全稀有植物的集团遗传学研究
东亚药用和食用植物的传统知识分析

전성호
  • 领域

    植物基因组学

  • 姓名

    Korean 全成浩

  • 职位

    教授

  • 研究室

    生命科学馆 8313

  • 联系方式

    033-248-2096

  • 电子邮件

学历

1986 ~ 1990 서울대학교 동물학과 학사 (생물학 전공)

1990 ~ 1992 서울대학교 분자생물학과 석사(세포생물학 전공)

1992 ~ 1998 서울대학교 분자생물학과 박사(분자면역학 전공)

主要经历

1998 ~ 1999 서울대학교 세포분화연구센터 박사후연구원

2000 ~ 2001 이스라엘 와이즈만 연구소 박사후연구원

2002 ~ 2003 미국 마운트사이나이 병원 박사후연구원

2003 ~ 2005 서울대학교 BK21 사업단 연구교수

2005 ~ 현재 한림대학교 생명과학과 교수

2012 ~ 현재 한림대학교 창업보육센터 센터장

研究及著作

■ 논문
- Fisetin-rich extracts of Rhus verniciflua stokes improve blood flow rates in mice fed both normal and high-Fat diets. 2016. J Med Food. 19(2):120-6.
- IL32γ activates natural killer receptor-expressing innate immune cells to produce IFNγ via dendritic cell-derived IL12. 2015. Biochem Biophys Res Commun.461(1):86-94.
- The HIF-1/glial TIM-3 axis controls inflammation associated brain damage under hypoxia. 2015. Nat Commun.6:6340. doi: 10.1038/ncomms7340.
- Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins. 2015. Sci Rep.5:14269.
- Application of in utero electroporation of G-protein coupled receptor (GPCR) genes, for subcellular localization of hardly identifiable GPCR in mouse cerebral cortex. 2014. Mol cells.37(7):554-561.
- nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer. 2014. Oncotarget5(11):3944-3955.
- TopBP1 deficiency impairs V(D)J recombination during lymphocyte development. 2014. EMBO J. 33(3):217-228.
- Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma. 2013. Oncogene32(32):3722-31.
- Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: evidence of possible mediation by host tRNA-derived small noncoding RNAs. 2013. BMC Infect Dis.23;13:285.
- Involvement of the cAMP response element binding protein, CREB, and Cyclin D1 in LPA-induced proliferation of P19 embryonic carcinoma cells. 2012. Mol cells.34(3):323-328.
- A tumor surveillance model: A non-coding RNA senses neoplastic cells and its protein partner signals cell death. 2012. Int. J. Mol. Sci.13(10):13134-13139.
- Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR. 2012. FEBS Lett.586(19):3477-3484.
- DNA Aptamers against the Receptor Binding Region of Hemagglutinin Prevent Avian Influenza Viral Infection. 2011. Mol. cells32(6):527-533.
- Activation of natural killer T cells inhibits the development of induced regulatory T cells via IFNγ. 2011. Biochem. Biophys. Res. Commun..411(3):599-606.
- Gold nanoparticle-based colorimetric detection of kanamycin using a DNA aptamer. 2011. Anal. Biochem.415(2):175-81.
- Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity. 2011. RNA 17(6):1076-89.
- Galectin-3 exerts cytokine-like regulatory actions through the JAK-STAT pathway. 2010. J Immunol.185(11):7037-46.
- Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells. 2009. Mol Cells.28(6):553-558.
- The Effect of CD28 Stimulation on in vitro Generation of Regulatory T Cells with IL2 and TGFβ. 2008. GENES &GENOMICS. 30(6): 555-561.
- Down-Regulation of the SWI/SNF Chromatin Remodeling Activity by TCR Signaling Is Required for Proper ThymocyteMaturation. 2007. J Immunol.178(11):7088-96.
- SRG3 interacts directly with the major components of the SWI/SNF chromatin remodeling complex and protects them from proteasomal degradation. 2007. J Biol Chem.282(14):10614-24.
- Notch1 Confers Thymocytes a Resistance to GC-induced Apoptosis via Deltex1 by Blocking the Recruitment of p300 to E2A/HEB and Regulating the SRG3 Expression. 2006. Cell death differ.13:1495-1505.
- Expression of SRG3, a Core Component of Mouse SWI/SNF Chromatin Remodeling Complex, Is Regulated by Cooperative Interactions between Sp1/Sp3 and Ets Transcription Factors. 2005. Biochem. Biophys. Res. Commun. 338:1435-1446.
- Ecto-and exo-protein kinases in Schistosoma mansoni: regulation of surface phosphorylation by acetylcholine and identification of the alpha subunit of CKII as a major secreted protein kinase. 2005. J. Parasitol. 91:756-63.
- Modulation of androgen receptortransactivation by the SWI3-related gene product (SRG3) in multiple ways. 2005. Mol. Cell Biol. 25(12) 4841-4852.
- A DNA aptamer prevents influenza infection by blocking the receptor binding region of the viral haemagglutinin. 2004. J. Biol.Chem.279(46): 48410-48419.
- Nitric oxide inhibits glucocorticoid-induced apoptosis oft hymocytes by down-regulating the SRG3 expression. 2004. J. Biol.Chem. 279(33): 34373-34379.
- E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression. 2004. J. Biol. Chem. 279(21): 21916-23.
- T-cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3 expression via Ras activation. 2004. J. Biol. Chem. 279(21): 21903-15.
- Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. 2003. Nucleic Acids Res.31(24):7165-74.
- Overexpression of SRG3/SWI3 protein disrupts the cell cycle progression in mature T cells and yeast. 2002. Korean J. Biol.Sci. 6:335-339.
- Intranasal immunization with synthetic recombinant vaccine containing multiple epitopes of influenza virus. 2002. Vaccine20: 2772-2780.
- Immunization with Influenza Virus Hemagglutinin Globular Region Containing the Receptor-Binding Pocket. 2002. Viral Immunol. 15: 165-176.
- Notch1 confers developing thymocytes a resistance to glucocorticoid induced apoptosis by down-regulating SRG3 expression. 2001. Proc. Natl.Acad. Sci. U.S.A. 98:10267-72.
- Two species of mRNAs for the fyn proto-oncogene are produced by an alternative polyadenylation. 1998. Mol. &Cells8:746-749.
- Down-regulation of Tcf-1 expression by activation-induced apoptosis of T cell hybridoma. 1998. Korean J. Biol.Sci. 2:403-410.
- Expression of Tcf-1 mRNA and surface TCR/CD3 complexes are reduced during apoptosis of T-cells. 1998. Int. Immunol. 10:1519-1527.
- A new mouse gene, SRG3, related to the SWI3of Saccharomyces cerevisiae, is required for apoptosis induced by glucocorticoids in thymoma cell line. 1997. J. Exp. Med. 185:1827-1836.
- Overexpressed RAD4 protein required for excision repair of Saccharomyces cerevisiaeis toxic to the host Escherichia coli. 1994. In Vitro Toxicol. 7:269-275.
- Expression of RAD4gene of Saccharomyces cerevisiae that can be propagated in Escherichia coli without inactivation. 1993. Biochem. Biophys. Res. Commun. 193:191-197.
- The isolated RAD4gene required for nucleotide excision repair in Saccharomyces cerevisiaedose not contain a suppressor gene. 1990. Korean J. Genetics. 12:147-155.
 

■ 저서
- 세균과 세균바이러스의 유전학. 2015. 필수 유전학 6판. by D.L. Hartl (ed. 양재섭 외). chap. 7, pp 226-259. 바이오사이언스 출판
- 번역, 조절 RNA, 2014. 왓슨 분자생물학 7판 by J. Watson (ed. 양재섭 외). chap. 15, pp. 509-571; chap. 20, pp. 701-732 바이오사이언스 출판
- 세포생물학, 2014. by G. Plopper 범문 에듀케이션
- 전이. 2013. 분자생물학 5판 by R.F. Weaver, (ed. 최준호 외). chap. 23, pp. 677-701. 라이프사이언스
- 필수세포생물학 2판. 2003. by B.Alberts (ed. 박상대 외) 교보문고
- Apoptosis in immune system. 1998. 유전. 2: 129-146.
 

■ 특허
- DNA aptamers and their mixture for the prevention of infection and detection of avian influenza virus, H9N2. 2008. Korea 10-2008-0039199.
- Nucleic acid molecules, polypeptides, antibodies and compositions for treating and detecting influenza virus infection. 2010. US 7786279 B2
- DNA aptamer binding to kanamycin with specificity. 2010. Korea 10-1263450
- DNA aptamer binding to ampicillin with specificity. 2010. Korea 10-1258600
- DNA aptamer binding to sulfadimethoxine with specificity. 2010. Korea 10-1263449
- Functional health food composition using color food for anti-oxidative and anti-inflammatory effect and method for manufacturing the same. 2015. Korea 10-2015-0024442

其它

■ 학회활동
- 한국세포분자생물학회 재무위원
- 대한면역학회 정회원
- 한국유전학회 정회원


■ 주요 연구주제
- non-coding RNA에 의한 면역세포의 분화 및 암 조절 기전 연구: 단백질을 암호화하지 않는 비번역 RNA가 면역기능을 담당하는 대식세포의 분화와 활성 조절에 관여하는 신호전달과 유전자 발현에 중요한 조절자로서 기능할 가능성에 대한 연구. 이 RNA는 세포의 증식과 암세포의 발병과정에서도 중요한 역할을 한다는 것을 밝힘으로써, 항암 또는 면역질환의 치료제 발굴에 관한 단서를 제공함.
- 항-바이러스 치료제 및 백신 개발: 인플루엔자 바이러스 감염을 억제하는 치료제 및 백신 후보물질의 발굴과 관련된 연구
- 기능성 천연소재의 면역활성 효능평가 및 조절기전 분석: 국내외 다양한 식물에서 유래한 면역조절 후보물질의 효능평가를 통한 기능성 식품, 화장품, 면역조절 치료제 발굴과 관련된 연구

정동훈
  • 领域

    植物基因组学

  • 姓名

    Korean 全东薰

  • 职位

    生命科学系 助教授

  • 研究室

    生命科学馆 8306

  • 联系方式

    033-248-2092

  • 电子邮件

学历

理学博士 浦项工科大学生命科学系

理学硕士, 浦项工科大学生命科学系

理学士, 延世大学生物学系

主要经历

助教, 翰林大学生命科学系

博士后研究员.

博士后研究员, 浦项工科大学

研究及著作

■ 연구 및 저서

- Chung PJ, Jung H, JeongD-H,Ha SH, Choi YD, Kim JK. (2016) Transcriptome profiling of drought responsive noncoding RNAs and their target genes in rice. BMC Genomics.17: 563

-  Jeong D-H(2016) Functional diversity of microRNA variants in plants J. Plant Biol.59: 303-310

- Kim C-Y, Vo KTX, Nguyen CD, JeongD-H, Lee S-K, Kumar M, Kim S-R, Park S-H, Kim J-K, Jeon J-S. (2016) Functional analysis of a cold-responsive rice WRKY gene, OsWRKY71. Plant Biotechnology Reports.10:13-23

- Schmidt SA, Foley PL, JeongD-H, Rymarquis LA, Doyle F, Tenenbaum SA, Belasco JG,, and Green PJ. (2015) Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res. 43: 309-323

-  Jeong D-H, Schmidt SA, Rymarquis LA, Park S, Ganssmann M, German MA, Accerbi M, Zhai J, De Paoli E, Fahlgren N, Fox SE, Garvin DF, Mockler TC, Carrington JC, Meyers BC, and Green PJ. (2013) Parallel analysis of RNA ends enhances global investigation of miRNAs and target RNAs of Brachypodium distachyon.Genome Biology 14:R145

-  Jeong D-H, and Green PJ. (2013) The role of rice microRNAs in abiotic stress responses. J. Plant Biol.56: 187-197 (review)

-  Jeong D-H*, Thatcher SR*, Brown RSH, Zhai J, Park S, Rymarquis LA, Meyers BC, and Green PJ. (2013)Comprehensive investigation of microRNAs enhanced by analysis of sequence variants, expression patterns, ARGONAUTE loading and target cleavage. Plant Physiol.162:1225-1245 (*co-first authors)

-  Jeong D-H, and Green PJ. (2012) Methods for validation of miRNA sequence variants and the cleavage of their targets. Methods 58:135-143

- Song X, Li P, Zhai J, Zhou M, Liu B, Ma L, JeongD-H, Nakata M, Cao S, Liu C, Chu C, Wang X-J, Green PJ, Meyers BC, and Cao X.(2012) Role of DCL4 and DCL3b in rice phased small RNA biogenesis. Plant J. 69:462-474

-  Jeong D-H, Park S, Zhai J, Gurazada SGR, De Paoli E, Meyers BC, and Green PJ. (2011) Massive analysis of rice small RNAs: Mechanistic implication of regulated miRNAs and variants for differential target RNA cleavage. Plant Cell23: 4185-4207

- Zhai J, JeongD-H,De Paoli E,Park S,Rosen BD, Li Y, González AJ,Yan Z, Kitto SL, Grusak MA, Jackson SA, Stacey G, Cook DR, Green PJ, Sherrier DJ, Meyers BC. (2011) microRNAs as Master Regulators of the Plant NB-LRR Defense Gene Family via the Production of Phased, Trans-acting siRNAs. Genes and Development25:1540

- Young ND, Debellé F, Oldroyd G, Geurts R, Cannon SB, Mayer KFX, Gouzy J, Van de Peer Y, Schoof H, Udvardi MK, Cook DR, Meyers BC, Spannagl M, Cheung F, De Mita S, Proost S, Krishnakumar V, Gundlach H, Zhou S, Mudge J, Bharti AK, Benedito VA, Murray JD, Naoumkina MA, Rosen B, Silverstein KA, Tang H, Rombauts S, Zhao PX, Zhou P, Barbe V, Bardou P, Bechner M, Bellec A, Berger A, Bergès H, Bidwell S, Bisseling T, Choisne N, Couloux A, Denny R, Deshpande S, Doyle JJ, Dudez A-M, Farmer AD, Fouteau S, Franken C, Gibelin C, Gish J, González AJ, Green PJ, Hallab A, Hartog M, Hua A, Humphray S, JeongD-H,Jing Y, Jöcker A, Kenton SM, Kim D-J, Kathrin Klee, Lai H, Lang C, Lin S, Macmil SL, Magdelenat G, Matthews L, McCorrison J, Monaghan EL, Mun J-H, Najar FZ, Nicholson C, Noirot C, Paule CR, Poulain J, Prion F, Qin B, Qu C, Retzel EF, Riddle C, Sallet E, Samain S, Samson N, Saurat O, Scarpelli C, Schiex T, Segurens B, Seigfried M, Severin A, Sherrier DJ, Shi R, Sims S, Sinharoy S, Sterck L, Vasylenko I, Viollet A, Wang K, Wang B-B, Wang X, Warfsmann J, Weissenbach J, White DD, White JD, Wiley GB, Wincker P, Xing Y, Yang L, Yao Z, Ying F, Zhai J, Zhou L, Zuber A, Dénarié J, Dixon RA, May GD, Schwartz DC, Rogers J, Quétier F, Town CD, Roe BA. (2011) The Medicago Genome Provides Insight into the Evolution of Rhizobial Symbioses. Nature480:520-524

- Lee Y-S, JeongD-H, Lee D-Y, Yi J, Ryu C-H, Kim SL, Jeong HJ, Choi SC, Jin P, Yang J, Choi L-H, Choi H, and An G (2010) OsCOL4 is a constitutive flowering repressor upstream of Ehd1 and downstream of OsphyB. Plant J. 63:1830.

- Joshi T, Yan Z, Libault M, JeongD-H, Park S, Green PJ, Sherrier Dj, Farmer A, May G, Meyers BC, Xu D, Stacey G (2010) Prediction of novel miRNAs and associated target genes in Glycine max. BMC Bioinformatics11 (Suppl 1):S14.

其它

■ 주요 연구주제

- RNA Genomics: 차세대염기서열분석기술(Next Generation Sequencing technology)를이용하여small RNA 및mRNA와같은다양한전사체(transcriptome)를유전체수준에서연구함

- Crop Functional Genomics: 벼의꽃발달관여유전자및환경스트레스관련유전자의발굴과형질전환식물체개발을통한기능유전체연구를수행하고있음

- Post-transcriptional Gene Regulation: microRNA를포함한small RNA가전사후단계에서유전자발현을조절하는기작을연구하며, RNA degradome 분석을통한RNA 분해기작을주로연구함.

 

■ 학회활동

- 한국식물학회

- 한국유전학회

 

■ 수상

- 한국식물학회JPB 논문상(2016)

김봉수
  • 领域

    微生物学

  • 姓名

    Korean 金峰秀

  • 职位

    生命科学系助教

  • 研究室

    生命科学馆 8309

  • 联系方式

    033-248-2093

  • 电子邮件

学历

首尔大学应用生物化学部 学士

首尔大学生命科学部 博士

主要经历

首尔大学微生物研究所 博士后研究员

美国药监局(US F.D.A)毒性学研究所 博士后研究员

(株)CHUNLAB生物信息研究所研究所所长

翰林大学生命科学系 助教

研究及著作

韩国微生物学会

韩国微生物生命工学会

其它

人类微生物体研究(Human Microbiome) 人类的身体中存在着比人类细胞和遗传因子数明显多的各种微生物。对这些微生物的构成和作用, 将通过利用大容量碱基序列分析装备-Next-Generation Sequencer进行研究和发现。通过这些研究各种疾病和微生物群集的相关性和维持健康的应用方案。发现的各种结果可用于产业、保健学领域。
微生物元基因组学研究(Metagenomics) 包括我们人类在内的地球上的所有环境都是由微生物复杂地构成的, 并与其共存。但大多数的微生物在实验室无法培养。对环境中实际存在的微生物的构成和生态作用, 将利用元基因组学来研究。通过对实际我们生活环境中的微生物群集的研究(Household microbiome)和各种环境的微生物群集研究(Ecosystem microbiome)结果有助于树立各种环境的管理方案。
微生物基因组研究(Genomics) 通过有益的微生物种和有害的微生物种的全基因组 (Whole genome)分析研究其作用和进化生态的相关性。通过研究考察各种遗传因子的检出法和遗传因子的利用技法。